Baked High-Protein Pepperoni Stromboli

Featured in: Simple Comfort Plates

This hearty Italian-American classic wraps pizza dough around a savory filling of lean ground beef, spicy pepperoni slices, and a blend of mozzarella and Parmesan cheeses. The dough is brushed with egg for a golden, glossy finish, then baked until perfectly crispy. Steam vents ensure even cooking throughout. Each serving delivers 37 grams of protein, making it as nutritious as it is delicious. Slice and serve with warm marinara for dipping, or pair with a crisp salad for a complete meal.

Updated on Sun, 08 Feb 2026 12:58:00 GMT
Golden-baked High-Protein Pepperoni Stromboli, sliced to reveal layers of seasoned ground beef and melted mozzarella cheese. Pin it
Golden-baked High-Protein Pepperoni Stromboli, sliced to reveal layers of seasoned ground beef and melted mozzarella cheese. | freshymeals.com

There's something about the smell of ground beef browning in a hot skillet that makes you feel like you're actually cooking something worthwhile. Years ago, I was experimenting with ways to make pizza night feel more substantial, and that's when stromboli entered my life as the answer to "how do I feed four hungry people with something that feels both indulgent and actually good for them." This baked high-protein version became my go-to because it checks every box without requiring any culinary wizardry. The first time I served it, someone asked if I'd ordered it from an Italian restaurant, which was the highest compliment I could've asked for.

I made this for my coworkers one Friday, bringing a still-warm stromboli to the break room, and watched grown adults lose it over lunch. One person cut it open and steam rose up, carrying that aroma of melted cheese and Italian herbs, and everyone just went quiet for a moment. That's when I realized this wasn't just a recipe I liked, it was something that could actually change how people thought about food at work. It became the unofficial office favorite, and I've made it at least a dozen times since.

Ingredients

  • Pizza dough (1 pound): Store-bought saves time and honestly makes no difference to the final result, but homemade gives you control over thickness and texture if you're feeling ambitious.
  • Lean ground beef (8 oz): The key word here is lean - it browns better, renders less fat, and keeps your protein count high without greasiness.
  • Pepperoni slices (2 oz): Don't skimp on quality here because pepperoni really is the star when you bite in, and cheap stuff tastes thin and papery.
  • Shredded mozzarella cheese (2 cups): Use whole milk mozzarella if possible, and freshly shredded cheese melts more evenly than pre-shredded.
  • Grated Parmesan cheese (1/2 cup): This adds a sharpness that prevents the stromboli from tasting one-note.
  • Onions (1/2 cup chopped): They soften completely and add sweetness that balances the spice and salt.
  • Garlic (2 cloves minced): Mince it fine so it distributes through the filling and doesn't leave you with big chunks.
  • Dried Italian herbs (1 tsp): This is where you decide the flavor profile - oregano leans earthier, basil leans brighter.
  • Crushed red pepper flakes (1/4 tsp, optional): I always add this because it gives a gentle heat that builds as you eat.
  • Salt and black pepper: Season as you go, especially after browning the meat.
  • Egg (1, beaten): This creates that glossy golden finish and helps everything bake evenly.
  • Olive oil (1 tbsp): For sautéing and it keeps the filling from sticking to the pan.
  • Marinara sauce: Warm it while the stromboli bakes so it's ready to serve alongside.

Instructions

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Get your oven ready:
Preheat to 400°F and line a baking sheet with parchment paper so nothing sticks.
Build your flavor base:
Heat olive oil in a skillet, sauté onions until they turn translucent and smell sweet, then add garlic just long enough to wake it up - about 30 seconds.
Brown the beef properly:
Add your ground beef and break it up as it cooks, making sure you get some color on the pieces and not just gray mush. Season everything generously with salt, pepper, Italian herbs, and red pepper flakes if you're using it.
Cool before assembly:
Let the beef mixture sit for about 5 minutes so it's not steaming hot when you layer it into the dough - this prevents the dough from getting too soft.
Roll out your canvas:
On a lightly floured surface, stretch the pizza dough into a rectangle about 12 by 16 inches, working gently and letting it rest if it fights back.
Layer with intention:
Spread the cooled beef mixture evenly over the dough, leaving a 1-inch border all around so you have space to seal it. Layer pepperoni on top, then sprinkle both cheeses evenly.
Roll it tight:
Starting from a long edge, roll the dough tightly into a log like you're making cinnamon rolls, then pinch the seams and ends to seal everything together.
Position and seal:
Place the stromboli seam-side down on your parchment-lined sheet, brush the top with beaten egg, and make 3 or 4 diagonal slits with a sharp knife so steam can escape.
Bake until golden:
Bake for 25 to 30 minutes until the top is deep golden brown and the whole thing feels firm when you gently press it. Let it rest for 5 minutes before slicing - this keeps the filling from spilling everywhere.
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Freshly baked High-Protein Pepperoni Stromboli resting on a wooden board with a small bowl of marinara dipping sauce. Pin it
Freshly baked High-Protein Pepperoni Stromboli resting on a wooden board with a small bowl of marinara dipping sauce. | freshymeals.com

My partner came home one evening to find the apartment filled with that warm, yeasty, cheesy aroma, and they literally dropped their bag and just asked "is that what I think it is?" That moment, before they even tasted it, felt like I'd done something right. Food that fills your home with anticipation before anyone even takes a bite is food worth making again.

Why This Stromboli Works as a High-Protein Meal

The ground beef delivers serious protein in a way that feels natural and delicious, not like you're forcing yourself to eat something for your fitness goals. The two types of cheese add richness that makes your brain register this as a treat, which means you're actually satisfied after eating it. When you slice into a warm stromboli and see all those layers of filling, your body understands that it's getting real nutrition, not just empty carbs.

How to Store and Reheat

Leftover stromboli keeps beautifully in the refrigerator for about three days, and reheats perfectly in a 350°F oven for about 10 minutes until warm through. You can also wrap individual slices in foil and warm them gently, which prevents the edges from drying out. Cold stromboli is actually not bad if you're in a rush, though it's definitely better warm.

Variations and Mix-Ins That Work

Once you understand the basic structure, this stromboli becomes a canvas for whatever you have on hand. I've added sautéed bell peppers, spinach, mushrooms, and even roasted red peppers, and every version has been good. The key is keeping your fillings cooked and relatively dry so the dough stays intact and bakes evenly.

  • Swap the beef for ground turkey or chicken if you want lower fat, and the stromboli will still be absolutely delicious.
  • Add a thin layer of marinara inside before rolling if you want more sauce flavor baked right in.
  • Try hot Italian sausage instead of beef for a richer, spicier version that makes people take notice.
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Steam rising from a warm High-Protein Pepperoni Stromboli with crispy crust, pepperoni slices, and savory beef filling. Pin it
Steam rising from a warm High-Protein Pepperoni Stromboli with crispy crust, pepperoni slices, and savory beef filling. | freshymeals.com

This stromboli has earned its place in my regular rotation because it makes people happy and doesn't demand much from me in return. Every time I make it, I'm reminded that good food doesn't have to be complicated to feel special.

Recipe FAQs

Can I make the dough ahead of time?

Yes, prepare the dough up to 24 hours in advance and store it wrapped in the refrigerator. Let it come to room temperature for 30 minutes before rolling.

What other meats work well in this filling?

Italian sausage, cooked crumbled bacon, or diced ham make excellent additions. You can also use turkey or chicken for a lighter version.

How do I prevent the bottom from getting soggy?

Ensure the beef mixture has cooled slightly before assembling. Place the stromboli directly on a preheated baking stone or use parchment paper for better air circulation.

Can I freeze stromboli for later?

Absolutely. Bake completely, cool, wrap tightly in plastic and foil, then freeze for up to 3 months. Thaw overnight and reheat at 350°F for 15-20 minutes.

What vegetables can I add without making it soggy?

Sautéed bell peppers, mushrooms, or spinach work well when cooked beforehand to remove excess moisture. Avoid watery vegetables like fresh tomatoes.

How do I know when it's fully cooked?

The crust should be deep golden brown and an instant thermometer inserted into the center should read at least 165°F. The cheese should be melted and bubbling through the vents.

Baked High-Protein Pepperoni Stromboli

Golden-baked stromboli rolled with beef, pepperoni, and mozzarella. Hearty, protein-packed Italian-American classic ready in under an hour.

How long to prep
20 min
Time to cook
30 min
Overall time
50 min
Recipe by Freshymeals Lily Carter

Dish category Simple Comfort Plates

Skill level Medium

Cuisine type Italian-American

Makes 4 Serving size

Dietary details None specified

What you need

Dough

01 1 pound pizza dough, store-bought or homemade

Meat & Cheese Filling

01 8 ounces lean ground beef
02 2 ounces pepperoni slices
03 2 cups shredded mozzarella cheese
04 1/2 cup grated Parmesan cheese

Vegetables & Seasoning

01 1/2 cup chopped onions
02 2 cloves garlic, minced
03 1 teaspoon dried Italian herbs
04 1/4 teaspoon crushed red pepper flakes
05 Salt and black pepper to taste

Extras

01 1 large egg, beaten
02 1 tablespoon olive oil
03 Marinara sauce for serving

Steps to follow

Step 01

Prepare Oven: Preheat oven to 400°F and line a baking sheet with parchment paper.

Step 02

Sauté Aromatics: Heat olive oil in a large skillet over medium heat. Sauté chopped onions for 2 to 3 minutes until translucent. Add minced garlic and cook for 30 seconds.

Step 03

Brown Beef: Add lean ground beef to the skillet, breaking it into small pieces as it cooks. Season with salt, pepper, Italian herbs, and red pepper flakes. Cook until browned with no pink remaining, approximately 8 to 10 minutes. Remove from heat and cool for 5 minutes.

Step 04

Roll Dough: On a lightly floured surface, roll out pizza dough into a large rectangle approximately 12 by 16 inches.

Step 05

Layer Filling: Spread the cooled beef mixture evenly over the dough, leaving a 1-inch border on all sides.

Step 06

Add Toppings: Arrange pepperoni slices over the beef. Sprinkle shredded mozzarella and grated Parmesan cheese evenly across the top.

Step 07

Roll and Seal: Starting from a long edge, tightly roll the dough into a log. Pinch the ends and seam securely to seal.

Step 08

Position on Baking Sheet: Place the stromboli seam-side down on the prepared baking sheet. Brush the top with beaten egg.

Step 09

Score for Steam Release: Using a sharp knife, make 3 to 4 diagonal slits across the top to allow steam to escape during baking.

Step 10

Bake: Bake for 25 to 30 minutes until golden brown and cooked through. Remove from oven and let rest for 5 minutes.

Step 11

Finish and Serve: Slice the stromboli and serve warm with marinara sauce.

Tools you’ll need

  • Large skillet
  • Rolling pin
  • Baking sheet
  • Parchment paper
  • Pastry brush
  • Sharp knife

Allergy info

Always check each ingredient for allergens and talk to a professional if unsure.
  • Contains wheat gluten
  • Contains dairy proteins from mozzarella and Parmesan cheese
  • Contains eggs
  • Pepperoni may contain additional allergens; verify labels for sensitivities

Nutrition info (per portion)

Nutrition details are for reference only, not a substitute for health advice.
  • Calories per serving: 520
  • Fat content: 25 g
  • Carbohydrates: 35 g
  • Protein amount: 37 g